Towards an Understanding of the Genome and the Brain
Friday, October 22, 2010
Number One on F1000!
The faculty of 1000 (F1000) is a post-publication peer review process performed by leading scientists that ranks publications in a variety of scientific fields. Our paper has the number one spot in Neuroscience! Fantastic.
Yesterday afternoon, Chris gave a talk at McLean Hospital about his great work [1] on transgenerational genetic effects in the brains of mice. After his talk, I told Chris that such effects are almost as common in frequency and magnitude as Mendelian inheritance, a commonality just described in a new paper by Vicki Nelson et al. [2] which used chromosome substitution strains (CSS) also in a murine model.
I also told Chris about the new Whitehead Institute discovery that the human Y chromosome has 78 genes and has been evolving rapidly [3]. Additionally, there is some interesting work on the epigenetic effects of polymorphic Y chromosomes [4].
There is now some molecular evidence that cortical synaptic growth occurs mainly during the first decade of life in humans [5], and a wide variety of evidence that the schizophrenic brain resembles a juvenile brain, for example, paper [6].
Best, Charles Stromeyer Jr. cstromeyer@post.harvard.edu
[1] Gregg C, et al. Sex-specific parent-of-origin allelic expression in the mouse brain. Science. 2010 Aug 6;329(5992):682-5. Gregg C, et al. High-resolution analysis of parent-of-origin allelic expression in the mouse brain. Science. 2010 Aug 6;329(5992):643-8. [2] http://www.futuremedicine.com/doi/abs/10.2217/epi.10.26 [3] Hughes JF, et al. Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content. Nature. 2010 Jan 28;463(7280):536-9. [4] Lemos B, Branco AT, Hartl DL. Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15826-31. [5] Webster MJ, Elashoff M, Weickert CS. Molecular evidence that cortical synaptic growth predominates during the first decade of life in humans. Int J Dev Neurosci. 2010 Oct 1. [Epub ahead of print] [6] Torkamani A, et al. Coexpression network analysis of neural tissue reveals perturbations in developmental processes in schizophrenia. Genome Res. 2010 Apr;20(4):403-12.
2 comments:
Great work, Chris!
Yesterday afternoon, Chris gave a talk at McLean Hospital about his great work [1] on transgenerational genetic effects in the brains of mice. After his talk, I told Chris that such effects are almost as common in frequency and magnitude as Mendelian inheritance, a commonality just described in a new paper by Vicki Nelson et al. [2] which used chromosome substitution strains (CSS) also in a murine model.
I also told Chris about the new Whitehead Institute discovery that the human Y chromosome has 78 genes and has been evolving rapidly [3]. Additionally, there is some interesting work on the epigenetic effects of polymorphic Y chromosomes [4].
There is now some molecular evidence that cortical synaptic growth occurs mainly during the first decade of life in humans [5], and a wide variety of evidence that the schizophrenic brain resembles a juvenile brain, for example, paper [6].
Best,
Charles Stromeyer Jr.
cstromeyer@post.harvard.edu
[1] Gregg C, et al. Sex-specific parent-of-origin allelic expression in the mouse brain. Science. 2010 Aug 6;329(5992):682-5.
Gregg C, et al. High-resolution analysis of parent-of-origin allelic expression in the mouse brain. Science. 2010 Aug 6;329(5992):643-8.
[2] http://www.futuremedicine.com/doi/abs/10.2217/epi.10.26
[3] Hughes JF, et al. Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content. Nature. 2010 Jan 28;463(7280):536-9.
[4] Lemos B, Branco AT, Hartl DL. Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response,
and sexual conflict. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15826-31.
[5] Webster MJ, Elashoff M, Weickert CS. Molecular evidence that cortical synaptic growth predominates during the first
decade of life in humans. Int J Dev Neurosci. 2010 Oct 1. [Epub ahead of print]
[6] Torkamani A, et al. Coexpression network analysis of neural tissue reveals perturbations in developmental processes
in schizophrenia. Genome Res. 2010 Apr;20(4):403-12.
Thank you for your comments, Charles. Your ideas are very thought provoking.
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